The pepsin residue glycine-76 contributes to active-site loop flexibility and participates in catalysis
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منابع مشابه
The pepsin residue glycine-76 contributes to active-site loop flexibility and participates in catalysis.
Glycine residues are known to contribute to conformational flexibility of polypeptide chains, and have been found to contribute to flexibility of some loops associated with enzymic catalysis. A comparison of porcine pepsin in zymogen, mature and inhibited forms revealed that a loop (a flap), consisting of residues 71--80, located near the active site changed its position upon substrate binding....
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2000
ISSN: 0264-6021
DOI: 10.1042/0264-6021:3490169